Nucleosides. XXII. Pyrimidine Nucleosides of 4-Amino-4-deoxy-β-D-galactopyranose

Prebiotic Synthesis of Pyrimidine Nucleosides

Metabolism of pyrimidine L-nucleosides.

The intraperitoneal application of L-nucleosides (L-Cyd, L-Urd, L-dThd) to mice results in distribution of these compounds into tissues of the organism and their gradual excretion in the unchanged form. The residual level has been observed with L-ribonucleosides only and contains in addition to the L-nucleoside its 5'-phosphate. The phosphorylation in vivo is catalyzed by nucleoside-kinase and ...

NOVEL ANTI-INFLAMMATORY AND ANALGESIC AGENTS OF 5-CHROMENO-PYRIDO[2,3-d]PYRIMIDINE-4-YL DERIVATIVES AND S-NUCLEOSIDES ANALOGOUS

A series of new 3-formyl coumarine (2) was synthesized in good yields by replacement of chlorine atom by 2 amines. In addition, 5-chromeno-pyrido[2,3-d]pyrimidine-4-yl derivatives (5,6) was synthesized by cyclocondensation of 6aminouracil, the respective ketones and 3-formyl coumarine (2) in one pot-synthesis. Also 2-S-nucleosides analogous of pyrido[2,3-d]-pyrimidines (12-15) was synthesized b...

Analysis of urinary nucleosides. V. Identification of urinary pyrimidine nucleosides by liquid chromatography/electrospray mass spectrometry.

Modified urinary nucleosides are potentially invaluable in cancer diagnosis, as they reflect altered RNA turnovers. High-performance liquid chromatography (HPLC) was combined with full-scan mass spectrometry, tandem mass spectrometry, MS(n) analysis and accurate mass measurements in order to identify pyrimidine nucleosides purified from urine. Potential nucleosides were assessed by their eviden...

Synthesis of O-Amino Sugars and Nucleosides.

Nucleic acids and carbohydrates are essential biomolecules involved in numerous biological and pathological processes. Development of multifunctional building blocks based on nucleosides and sugars is in high demand for the generation of novel oligonucleotide mimics and glycoconjugates for biomedical applications. Recently, aminooxyl-functionalized compounds have attracted increasing research i...